Aini, Khollilah Nur (2022) Analisis Pengaruh Penstabil Polyethylene Glycol (PEG) Terhadap Karakteristik Nanopartikel Fe3O4/SiO2 Sebagai Media Terapi Hipertermia. Other thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Kanker merupakan salah satu penyebab utama kematian di dunia. Magnetic hyperthermia merupakan salah satu pengobatan kanker yang mneggunakan nanopartikel magnetit (Fe3O4). Sebelum diaplikasikan Fe3O4 biasanya dimodifikasi pada ermukaannya, salah satunya adalah dicoating dengan silika. Sebelum dimodifikasi, nanopartikel magnetit harus memiliki ukuran dan bentuk partikel yang homogen, dimana pada saat sintesis Fe3O4 perlu adanya agen penstabil. Pada penelitian ini dilakukan untuk mengetahui karakteristik pengaruh penstabil PEG terhadap nanopartikel Fe3O4/SiO2 sebagai media terapi hipertermia. Metode yang digunakan dengan co-presipitation dengan penambahan PEG dengan konsentrasi 2:5, 3:5 dan 4:5. Karakteristik yang dilakukan menggunakan XRD, FTIR, SEM, PSA, VSM, medan magnet AC dan hidrofobisitas. Hasil pengujian XRD, SEM dan PSA menunjukkan bahwa penambahan penstabil PEG dapat menurunkan ukuran partikel serta mengurangi aglomerasi dan saat dicoating dengan silika ukuran partikel mengalami peningkatan karena terdapat silika yang melingkupi Fe3O4. Ukuran partikel Fe3O4-PEG (2:5); (3:5); (4:5) memiliki nilai sebesar 155.96; 149.74; 149.67 nm sedangkan Fe3O4-PEG/SiO2 memiliki nilai sebesar 170.4; 106.68; 149.84 nm. Hasil VSM menunjukkan bahwa semua sampel bersifat superparamagnetik dengan nilai saturasi Fe3O4-PEG (2:5); (3:5); (4:5) sebesar 39.40; 48.76; 57.79 emu/g dan Fe3O4-PEG/SiO2 sebesar 30.92; 42.64; 50.81 emu/g. Hasil uji hidrofobisitas menyatakan bahwa semua sampel bersifat hidrofilik sehingga cocok untuk aplikasi biomedis. Analisis medan magnet AC menunjukkan bahwa semua sampel mengalami kenaikan temperatur apabila dikenai arus dari luar sehingga berpotensi untuk aplikasi terapi hipertermia.
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Cancer is one of the leading causes of death in the world. Magnetic hyperthermia is a cancer treatment that uses magnetite (Fe3O4) nanoparticles. Before applying Fe3O4 usually on the surface, one of which is coated with silica. Previously, magnetite nanoparticles had to have homogeneous particle size and shape, where at the time of Fe3O4 synthesis a stabilizing agent was needed. This research was conducted to determine the characteristics of the effect of PEG stabilizer on Fe3O4/SiO2 nanoparticles as a medium for hyperthermia therapy. The method used is coprecipitation with the addition of PEG with concentrations of 2:5, 3:5 and 4:5. The characteristics were carried out using XRD, FTIR, SEM, PSA, VSM, AC magnetic field and hydrophobicity. XRD, SEM and PSA test results showed that the addition of PEG stabilizer could reduce particle size and reduce agglomeration and when coated with silica the particle size increased due to the presence of silica surrounding Fe3O4. The particle size of Fe3O4-PEG (2:5);(3:5):(4:5) has a value of 155.96;149.74;149.67 nm while Fe3O4-PEG/SiO2 has a value of 170.4;106.68;149.84 nm. The VSM results show that all samples are superparamagnetic with a saturation value of Fe3O4-PEG (2:5);(3:5):(4:5) of 39.40; 48.76; 57.79 emu/g and Fe3O4-PEG/SiO2 of 30.92; 42.64; 50.81 emu/g. The results of the hydrophobicity test stated that all samples were hydrophilic so they were suitable for biomedical applications. Analysis of the AC magnetic field showed that all samples experienced an increase in temperature when exposed to external currents so that it was possible for hyperthermia therapy applications.
| Item Type: | Thesis (Other) |
|---|---|
| Additional Information: | RSMt 620.189 34 Ain a-1, 2022 |
| Uncontrolled Keywords: | Magnetit (Fe3O4), Silika, Terapi Hipertermia, Hyperthermia Therapy, Magnetite (Fe3O4) , Silica |
| Subjects: | T Technology > TP Chemical technology > TP248 Nanogels. Nanoparticles. |
| Divisions: | Faculty of Industrial Technology > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis |
| Depositing User: | Mr. Marsudiyana - |
| Date Deposited: | 10 Feb 2025 04:27 |
| Last Modified: | 10 Feb 2025 04:27 |
| URI: | http://repository.its.ac.id/id/eprint/118587 |
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