Analisis Pengaruh Konsentrasi HCl Terhadap Kinerja Enkapsulasi Rifampicin Dalam SBA-15 Sebagai Pengantar Obat Berbasis Inhalasi

Amanza, Aziz Rahman (2022) Analisis Pengaruh Konsentrasi HCl Terhadap Kinerja Enkapsulasi Rifampicin Dalam SBA-15 Sebagai Pengantar Obat Berbasis Inhalasi. Other thesis, Institut Teknologi Sepuluh Nopember.

Text 02511840000125-Undergraduate_Thesis.pdf Download (6MB)

Abstract

Pulmonary Drug Delivery adalah sistem pengantaran obat dengan rute inhalasi langsung menuju bagian alveolus pada paru–paru dan disebarkan melalui aliran darah. Nanopartikel silika mesopori digunakan sebagai zat pengikat yang membawa zat aktif berupa obat Rifampicin sebagai antibiotik anti-tuberkulosis berbentuk aerosol dihasilkan oleh dry powder inhaler. Penelitian ini bertujuan untuk menganalisis pengaruh konsentrasi HCl terhadap kemampuan enkapsulasi Rifampicin dalam nanopartikel silika mesopori SBA-15 dimana penggunaan HCl dalam sintesis nanopartikel silika mesopori SBA-15 berperan sebagai katalis dalam pembentukan nanopartikel silika mesopori SBA-15. Menganalisis kemampuan disolusi Rifampicin dalam nanopartikel silika mesopori SBA-15 menggunakan dry powder inhaler dan menganalisis kemampuan pembentukan aerosol hasil enkapsulasi Rifampicin dalam nanopartikel silika mesopori SBA-15 menggunakan dry powder inhaler. Penelitian ini terbagi menjadi 2 tahap yaitu sintesis nanopartikel silika mesopori SBA-15 menggunakan variasi konsentrasi HCl sebesar 1.5 M, 2 M, 3 M, dan 3.5 M. Dilanjutkan dengan proses enkapsulasi Rifampicin ke dalam nanopartikel silika mesopori SBA-15. Hasil pengujian menunjukkan penambahan konsentrasi HCl mempengaruhi morfologi batang (rod) nanopartikel silika mesopori SBA-15 yang semakin pendek dan tidak beraturan. Diperoleh sampel yang memiliki efisiensi enkapsulasi tertinggi yaitu sampel SR2 dengan konsentrasi HCl 2 M sebesar 42.191 %. Diperoleh hasil pengujian disolusi tertinggi terdapat pada sampel SR3.5 dengan konsentrasi HCl 3.5 M sebesar 91.13 %. Diperoleh hasil yang menunjukkan pengaruh morfologi disebabkan oleh penambahan HCl yang mempengaruhi hasil enkapsulasi dan disolusi. Diperoleh hasil pengujian aerodinamis aerosol pada sampel SR2 yang memiliki hasil tertinggi dengan FPF 10.4723% dan MMAD kurang dari 5 µm yang menunjukkan sampel dapat terdeposisi di saluran pernapasan bawah.
==================================================================================================================
Pulmonary Drug Delivery is a drug delivery system by inhalation route directly to the alveoli in the lungs and distributed through the bloodstream. Mesoporous silica nanoparticles are used as binding agents that carry the active substance in the form of the drug Rifampicin as an anti�tuberculosis antibiotic in aerosol form produced by dry powder inhalers. This study aims to analyze the effect of HCl concentration on the encapsulation ability of Rifampicin in SBA-15 mesoporous silica nanoparticles where the use of HCl in the synthesis of SBA-15 mesoporous silica nanoparticles acts as a catalyst in the formation of SBA-15 mesoporous silica nanoparticles. Analyzing the dissolution ability of Rifampicin in SBA-15 mesoporous silica nanoparticles using a dry powder inhaler and analyzing the aerosol formation ability of Rifampicin encapsulated in SBA-15 mesoporous silica nanoparticles using a dry powder inhaler. This research was divided into 2 stages, namely the synthesis of mesoporous silica nanoparticles SBA-15 using HCl concentration variations of 1.5 M, 2 M, 3 M, and 3.5 M. Followed by the encapsulation process of Rifampicin into SBA-15 mesoporous silica nanoparticles. The test results showed that the addition of HCl concentration affected the morphology of the rods of mesoporous silica SBA-15 nanoparticles which became shorter and irregular. The sample with the highest encapsulation efficiency was obtained, namely the SR2 sample with 2 M HCl concentration of 42.191%. The highest dissolution test results were found in the SR3.5 sample with a 3.5 M HCl concentration of 91.13%. The results showed that the morphological effect was caused by the addition of HCl which affected the encapsulation and dissolution results. The aerosol aerodynamic test results obtained on sample SR2 which has the highest yield with an FPF of 10.4723% and an MMAD of less than 5 m which indicates that the sample can be deposited in the lower respiratory tract.

Item Type:	Thesis (Other)
Additional Information:	RSMt 620.5 Ama a-1 2022
Uncontrolled Keywords:	Aerosol, Dry Powder Inhaler, Enkapsulasi, Konsentrasi, Nanopartikel Silika Mesopori SBA-15, Pulmonary Drug Delivery, Rifampicin.
Subjects:	T Technology > TP Chemical technology > TP248 Nanogels. Nanoparticles.
Divisions:	Faculty of Industrial Technology > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis
Depositing User:	Mr. Marsudiyana -
Date Deposited:	10 Feb 2025 08:50
Last Modified:	10 Feb 2025 08:50
URI:	http://repository.its.ac.id/id/eprint/118611

Actions (login required)

View Item