Pengaruh Penambahan Kitosan Terhadap Sifat Biokompatibilitas Komposit Kitosan – Hidroksiapatit Terdoping Seng Sebagai Kandidat Material Pengganti Tulang (Bone Substitute)

Pradita, Novihana Noor (2016) Pengaruh Penambahan Kitosan Terhadap Sifat Biokompatibilitas Komposit Kitosan – Hidroksiapatit Terdoping Seng Sebagai Kandidat Material Pengganti Tulang (Bone Substitute). Undergraduate thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Hidroksiapatit merupakan salah satu mineral penyusun tulang dan gigi yang sudah banyak diaplikasikan sebagai graft sintetik. Dikarenakan keterbatasan pada sifat mekaniknya, maka mulai dikembangkan Hidroksiapatit didoping Zinc (HA-Zn) untuk meningkatkan sifat tersebut. Penambahan kitosan diharapkan akan memperbaiki sifat antibakteri HA-Zn. Dalam penelitian ini akan dianalisa pengaruh persen berat kitosan terhadap sifat biokompatibilitas komposit Kitosan-HA-Zn (K/HA-Zn). Sintesis HA-Zn dilakukan menggunakan metode solgel. Pembuatan komposit K/HA-Zn dengan cara mencampur kitosan dalam asam asetat kemudian ditambahkan dengan HA-Zn. Sampel kemudian diuji menggunakan FTIR, XRD, SEM-EDAX, Uji Antibakteri, dan SBF. Pengujian biokompatibilitas menunjukkan bahwa aktivitas antibakteri efektif terhadap E.coli. Selain itu, ditemukan lapisan apatit pada permukaan komposit menandakan bioaktifitas yang baik dengan komposisi optimal pada penambahan 10% berat kitosan. ============================================================ Hydroxyapatite is one of constituent minerals of teeth and bone and already been widely used for synthetic bone graft. Due to the limitation on mechanical properties, researchers started to develop Zinc doped Hydroxyapatite (HA-Zn) to increase its mentioned properties. Addition of chitosan was expected to improve antibacterial properties of HA-Zn. The aim of the research is to analyze the effect of chitosan addition on biocompatibility properties of chitosan-HA-Zn (K/HA-Zn) composite. HA-Zn was synthesized using solgel method. K/HA-Zn composite was made by mixing chitosan in acetic acid then HAZn was added into the mixture. It is then characterized using XRD,FTIR, SEM-EDAX, Antibacterial testing, and SBF. Biocompatibility analysis showed that antibacterial activity was effective against E.Coli. In addition, apatite layer was seen on composite surface indicating good bioactivity with optimal composition on the addition of 10 percent weight of chitosan.

Item Type: Thesis (Undergraduate)
Additional Information: RSMt 620.118 Pra p-1
Uncontrolled Keywords: komposit, kitosan, biokompatibilitas, HAZn
Subjects: T Technology > TA Engineering (General). Civil engineering (General) > TA418.9 Composite materials. Laminated materials.
Divisions: Faculty of Industrial Technology > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis
Depositing User: EKO BUDI RAHARJO
Date Deposited: 15 Nov 2019 02:26
Last Modified: 15 Nov 2019 02:26
URI: http://repository.its.ac.id/id/eprint/71806

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