Fatimah, Ade Siti (2020) Analisis Pengaruh Variasi Massa Nanopartikel Silika Mesopori dari Sekam Padi sebagai Material Pengantar Obat terhadap Kemampuan Disolusi Paracetamol. Other thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Limbah sekam padi dapat diektraksi menjadi silika hal tersebut dikarenakan abu sekam padi memiliki kandungan silika yang tinggi yakni lebih dari 90%. Silika hasil ekstraksi dapat digunakan sebagai bahan sintesis silika mesopori. Silika mesopori mampu dimanfaatkan sebagai material pengantar obat. Sehingga penelitian bertujuan untuk menganalisis pengaruh variasi massa nanopartikel silika mesopori terhadap kemampuan disolusi parasetamol dan kemampuan floating tablet parasetamol. Penelitian ini dibagi menjadi 3 tahap yaitu sintesis SiO2 dari sekam padi, sintesis nanopartikel silika mesopori dan proses enkapsulasi paracetamol ke dalam nanopartikel silika mesopori serta pembentukan serbuk hasil enkapsulasi menjadi tablet. Pada proses enkapsulasi diberikan variasi perbandingan massa paracetamol dengan nanopartikel silika mesopori 1:1, 1:1,5 , 1:2. Berdasarkan pengujian kemampuan mass release menunjukkan rasio release terkontrol terbaik dengan perbandingan massa paracetamol dengan nanopartikel silika mesopori 1:1 yakni 20 jam. Pengujian disolusi juga menunjukkan bahwa hasil optimal ditunjukkan oleh sampel PCT:SiO2 = 1:1 dengan % disolusi sebesar 34,56.
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Rice husk waste can be extracted into silica because the rice husk ash has a high silica content which is more than 90%. The extracted silica can be used as material for synthesis of mesoporous silica. Mesoporous silica can be used as a drug delivery material. So the research aims to analyze the effect of adding paracetamol to the encapsulation ability and dissolution ability of the paracetamol in the variation of mesoporous silica nanoparticles from rice husk as a drug delivery material. This research was divided into 3 stages, SiO2 synthesis from rice husk, synthesis of mesoporous silica nanoparticles and the paracetamol encapsulation into mesoporous silica nanoparticles. In the encapsulation process a variation of the mass ratio of paracetamol and mesoporous silica nanoparticles is given: 1: 1, 1: 1.5, 1: 2. Based on the ability of mass release testing shows the best controlled release ratio with the comparison of the mass of paracetamol with 1: 1 mesoporous silica nanoparticles which is 20 hours. Dissolution testing also showed that the optimal results were shown by PCT samples: SiO2 = 1: 1 with the optimum dissolution% is 34,56%.
| Item Type: | Thesis (Other) |
|---|---|
| Additional Information: | RSMt 620.118 Fat a-1 2020 |
| Uncontrolled Keywords: | Sekam padi, silika mesopori, paracetamol, disolusi, mass release. |
| Subjects: | T Technology > TP Chemical technology T Technology > TP Chemical technology > TP248 Nanogels. Nanoparticles. |
| Divisions: | Faculty of Industrial Technology and Systems Engineering (INDSYS) > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis |
| Depositing User: | fatimah Ade siti |
| Date Deposited: | 07 Mar 2025 02:30 |
| Last Modified: | 07 Mar 2025 02:30 |
| URI: | http://repository.its.ac.id/id/eprint/73284 |
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