Sintesis dan Bioaktivitas Antibakterial Kompleks Tembaga(II)-2-hidroksibenziliden Benzohidrazida

Salsabilla, Shava Alifia (2024) Sintesis dan Bioaktivitas Antibakterial Kompleks Tembaga(II)-2-hidroksibenziliden Benzohidrazida. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Penelitian tentang senyawa antibakteri aktif menjadi bahasan fundamental akhir-akhir ini. Hal
ini disebabkan munculnya resistensi bakteri sehingga perlu dilakukan pengembangan agen
antibiotik alternatif. Obat antibakteri berbasis senyawa kompleks dapat menjadi target
terapeutik yang dapat menjawab permasalahan tersebut. Selain itu, kandungan logam
bioesensial dapat meminimalkan efek samping dan dapat meningkat efek farmakologis. Dalam
penelitian ini telah berhasil dilakukan sintesis ligan berbasis hidrazon, yaitu 2-
hidroksibenziliden benzohidrazida yang berupa padatan dengan warna putih kekuningan.
Kompleks Cu(II)-2-hidroksibenziliden benzohidrazida (padatan berwarna hijau) diperoleh dari
hasil reaksi ion Cu(II) dengan ligan 2-hidroksibenziliden benzohidrazida dengan perbandingan
mol logam:ligan yaitu 1:1. Ligan dan senyawa kompleks Cu(II) kemudian dilakukan
karakterisasi, analisis, dan uji antibakteri pada bakteri Staphylococcus aureus dan Escherichia
coli. Uji antibakteri dilakukan dengan metode difusi cakram. Nilai rata-rata zona inhibisi pada
2-hidroksibenziliden benzohidrazida adalah 7,15 ± 1,05 mm pada S. aureus dan 8,6 ± 0,5 mm
pada E. coli. Sedangkan nilai rata-rata zona inhibisi pada kompleks Cu(II)-2-hidroksibenziliden
benzohidrazida adalah 19,7 ± 4,2 mm pada S. aureus dan 13,45 ± 0,05 mm pada E. coli. Apabila
dibandingkan dengan kontrol positif (kloramfenikol), ligan dikategorikan sebagai antibakteri
yang resisten dan kompleks dikategorikan sebagai antibakteri yang sensitif pada S. aureus.
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Research on active antibacterial compounds has become a fundamental topic of discussion
recently. This causes the emergence of bacterial resistance so that it is necessary to develop
alternative antibiotic agents. Antibacterial drugs based on complex compounds can be a
therapeutic target that can answer this problem. In addition, the content of bioessential metals
can minimize side effects and can increase pharmacological effects. In this research, the
synthesis of a hydrazone-based ligand, namely 2-hydroxybenzylidene benzohydrazide, which
is a solid with a dark white color, has been successfully carried out. The Cu(II)-2-
hydroxybenzylidene benzohydrazide complex (green solid) is obtained from the reaction of
Cu(II) ions with the 2-hydroxybenzylidene benzohydrazide ligand with a metal: ligand mole
ratio of 1:1. Ligands and Cu(II) complex compounds were then characterized, analyzed and
tested antibacterial on Staphylococcus aureus and Escherichia coli bacteria. The antibacterial
test was carried out using the disc diffusion method. The average value of the zone of inhibition
for 2-hydroxybenzylidene benzohydrazide was 7.15 ± 1.05 mm in S. aureus and 8.6 ± 0.5 mm
in E. coli. Meanwhile, the average value of the inhibition zone for the Cu(II)-2-
hydroxybenzylidene benzohydrazide complex was 19.7 ± 4.2 mm in S. aureus and 13.45 ± 0.05
mm in E. coli. When compared with the positive control (chloramphenicol), the ligand was
suggested to be a resistant antibacterial and the complex was suggested to be a sensitive
antibacterial to S. aureus.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Antibakteri, Bakteri, Hidrazon, Metode Difusi Cakram, Senyawa Kompleks Cu(II) Antibacterial, Bacteria, Cu(II) Complex Compound, Disc Diffusion Method, Hydrazone
Subjects:	Q Science > QD Chemistry > QD251.2 Chemistry, Organic. Biochemistry Q Science > QD Chemistry > QD471 Chemical compounds - Structure and formulas Q Science > QD Chemistry > QD481 Chemical structure.
Divisions:	Faculty of Science and Data Analytics (SCIENTICS) > Chemistry > 47201-(S1) Undergraduate Thesis
Depositing User:	Shava Alifia Salsabilla
Date Deposited:	12 Aug 2024 03:16
Last Modified:	12 Aug 2024 03:16
URI:	http://repository.its.ac.id/id/eprint/114652

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