Senyawa Kompleks Tembaga(Ii)-Orto-Metilbenzyliden Benzohidrazida: Sintesis dan Aktivitas Antibakteri terhadap Staphyloccocus Aureus dan Escherichia Coli

Adama, Amelia Bella Putri (2024) Senyawa Kompleks Tembaga(Ii)-Orto-Metilbenzyliden Benzohidrazida: Sintesis dan Aktivitas Antibakteri terhadap Staphyloccocus Aureus dan Escherichia Coli. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Dalam beberapa tahun terakhir, penyakit yang disebabkan oleh adanya infeksi akibat bakteri terus meningkat cukup pesat akibat adanya resistensi antibiotik sehingga membuka koloni patogen untuk berkembang lebih banyak terutama dalam kondisi imun yang lemah. Perkembangan dalam penelitian obat antibakteri yang berbasis logam telah cukup luas untuk diteliti, akan tetapi pertumbuhan bakteri terus meningkat dan tidak bisa dikendalikan, sehingga diperlukan adanya keterbaruan dalam mencari obat yang resisten. Oleh karena itu, agen antibakteri baru berbasis senyawa kompleks perlu disintesis agar efektivitas obat menjadi lebih baik dan aman. Pada penelitian ini, senyawa kompleks disintesis dari ion logam Cu(II) dengan ligan 2-metilbenziliden benzohidrazida. Hasil sintesis dari senyawa kompleks berupa padatan polikristalin berwarna kuning tua dengan rendemen sebesar 43,47%. Kompleks Cu(II)-2- metilbenziliden benzohidrazida menyerap sinar UV-Vis pada panjang gelombang 356 nm. Hasil karakterisasi FTIR menunjukkan adanya ikatan koordinasi Cu-N dan Cu-O masing masing pada bilangan gelombang 450 cm-1 dan 515 cm-1 . Berdasarkan analisis unsur C, H, N, dan O dihasilkan rumus molekul kompleks yaitu C15H15ClCuN2O2. Interpretasi hasil XRD menunjukkan bahwa senyawa kompleks berbentuk polikristalin dan memiliki kemiripan dengan material standar. Berdasarkan uji antibakteri dengan metode difusi cakram , diperoleh nilai zona inhibisi sebesar 9,65 ± 3,45 mm untuk bakteri Gram positif (Staphyloccocus aureus) dan 11,95 ± 0,5 mm untuk bakteri Gram negatif (Escherichia coli). Berdasarkan nilai zona inhibisi yang diperoleh, senyawa kompleks Cu(II)-2 metilbenziliden benzohidrazida memiliki aktivitas antibakteri yang lebih efektif jika dibandingkan dengan ligan meskipun lebih rendah nilai zona inhibisinya dibandingkan kontrol.
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In recent years, diseases caused by bacterial infections have been increasing rapidly due to
antibiotic resistance, allowing pathogenic colonies to grow more, especially under weakened
immune conditions. The development of metal-based antibacterial drug has been widely
researched, but the growth of bacteria continues to increase and cannot be controlled, so there
is a need for novelty in finding resistant drugs. Therefore, it is necessary to synthesize new
complex compounds as new antibacterial. In this study, new antibacterial agents based on
complex compounds need to be synthesized for better and safer drug effectiveness. In this study,
complex compounds were synthesized from Cu(II) metal ions with 2-methylbenzyliden
benzohydrazide ligand. The synthesis result of the complex compound is dark yellow
polycrystalline solid with yield of 43,47%. The Cu(II)-2-methylbenziliden benzohydrazide
complex absorbed UV-Vis light at a wavelength of 356 nm. FTIR characterization results
showed the presence of Cu-N and Cu-O coordination bonds at wave numbers 450 cm-1
and 515
cm-1
, respectively. Based on the analysis of the elements C, H, N, and O the complex molecular
formula was C15H15ClCuN2O2. Interpretation of XRD result showed that the complex
compound was polycrystalline and has similarities with standard materials. Based on the
antibacterial test with disc diffusion method, the inhibition zone value was 9,65 ± 3,45 mm for
Gram-positive bacteria (Staphyloccocus aureus) and 11,95 ± 0,5 mm for Gram-negative
bacteria (Escherichia coli). Based on the value of the inhibition zone obtained, the Cu(II)-2
methylbenzyliden benzohydrazide complex compound has more effective antibacterial activity
when compared to the ligand even though the value of the inhibition zone is lower than the
control.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Antibakteri, Bakteri Gram Negatif, Bakteri Gram Positif, Hidrazon, Senyawa Kompleks Antibacteria, Gram Negative Bacteria, Gram Positive Bacteria, Complex Compound, Hydrazone
Subjects:	Q Science > QD Chemistry > QD251.2 Chemistry, Organic. Biochemistry Q Science > QD Chemistry > QD471 Chemical compounds - Structure and formulas Q Science > QD Chemistry > QD481 Chemical structure.
Divisions:	Faculty of Mathematics and Science > Chemistry > 47201-(S1) Undergraduate Thesis
Depositing User:	Amelia Bella Putri Adama
Date Deposited:	12 Aug 2024 03:13
Last Modified:	12 Aug 2024 03:13
URI:	http://repository.its.ac.id/id/eprint/114805

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