Analisis Pengaruh Volume Pelarut Metanol Dalam Enkapsulasi Sba-15 Terhadap Kinerja Rifampisin Sebagai Pengantar Obat Berbasis Inhalasi

Al-Ghiffary, Fatahillah (2022) Analisis Pengaruh Volume Pelarut Metanol Dalam Enkapsulasi Sba-15 Terhadap Kinerja Rifampisin Sebagai Pengantar Obat Berbasis Inhalasi. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Pulmonary Drug Delivery adalah teknologi yang berkembang di mana obat dihirup melalui paru-paru dan memasuki aliran darah melalui epitel alveolus. Dalam penelitian ini menggunakan nanopartikel silika Mesopori membawa zat aktif rifampisin untuk pengobatan antibiotik tuberculosis yang dilakukan secara inhalasi. Penelitian ini bertujuan untuk
menganalisis morfologi, struktur kristal dan pori SBA-15, menganalisis pengaruh volume pelarut metanol terhadap kemampuan enkapsulasi, kemampuan disolusi dan kemampuan pembentukan aerosol rifampisin dalam SBA-15 menggunakan dry powder inhaler. Penelitian ini terbagi menjadi 2 tahap yaitu sintesis nanopartikel silika mesopori dan proses enkapsulasi rifampisin ke dalam silika mesopori. Volume pelarut metanol divariasikan pada 56 mL (SBA�15/RIF I), 112 mL (SBA-15/RIF II), 169 mL (SBA-15/RIF III), dan 225 mL (SBA-15/RIF IV). Berdasarkan hasil pengujian, SBA-15 berbentuk batang panjang yang seragam dan komposisinya terdapat unsur Si dan O, hasil uji XRD menunjukan kristal yang amorfus dengan mesostruktur berbentuk heksagonal simetris, dan hasil uji BET luas permukaan pada sampel SBA-15 yang memiliki luas 668,521 m2 /g, dengan ukuran diameter porinya adalah 3,3976 nm dan volume total porinya yaitu 0,627 cc/g. sampel yang paling optimal adalah sampel SBA�15/RIF memiliki kemampuan enkapsulasi terbaik sebesar 82,94%, % disolusi sebesar 91,58% selama 45 menit dan Hasil pengujian aerodinamis aerosol dengan FPF 30 % dan MMAD yang dapat terdeposisi di saluran pernapasan bawah hingga alveolus.
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Pulmonary Drug Delivery is an evolving technology in which drugs are inhaled through the lungs and enter the bloodstream through the alveolar epithelium. In this study, Mesoporous silica nanoparticles carrying the active substance rifampin for the treatment of tuberculosis antibiotics were carried out by inhalation. This study aimed to analyze the morphology, crystal structure and pores of SBA-15, to analyze the effect of methanol solvent volume on the encapsulation ability, dissolution ability and the ability to form aerosols of rifampin in SBA-15 using a dry powder inhaler. This research was divided into 2 stages, namely the synthesis of mesoporous silica nanoparticles and the encapsulation of rifampicin into mesoporous silica. The volume of methanol solvent was varied at 56 mL (SBA-15/RIF I), 112 mL (SBA-15/RIF II), 169 mL (SBA-15/RIF III), and 225 mL (SBA-15/RIF IV). Based on the test results, SBA�15 is in the form of a uniform long rod and its composition contains Si and O elements, the XRD test results show an amorphous crystal with a symmetrical hexagonal mesostructure, and the BET test results on the surface area of the SBA-15 sample which has an area of 668,521 m2/ g, with a pore diameter of 3.3976 nm and a total pore volume of 0.627 cc/g. the most optimal sample is the SBA-15/RIF sample which has the best encapsulation ability of 82.94%, % dissolution of 91.58% for 45 minutes. Aerodynamic test results with 30% FPF and MMAD which can be deposited in the lower respiratory tract to the alveolus

Item Type:	Thesis (Other)
Additional Information:	RSMt 620.5 Alg a-1 2022
Uncontrolled Keywords:	Aerosol, Dry Powder Inhaler, Enkapsulasi, Metanol, Nanopartikel Silika Mesopori, Pulmonary Drug Delivery, Rifampisin, SBA-15
Subjects:	T Technology > TP Chemical technology > TP248.25.N35 Microencapsulation.
Divisions:	Faculty of Industrial Technology > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis
Depositing User:	Mr. Marsudiyana -
Date Deposited:	11 Dec 2024 05:49
Last Modified:	11 Dec 2024 05:49
URI:	http://repository.its.ac.id/id/eprint/115945

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