Pra Desain Pabrik L-Metionin Dari Gula Kristal Mentah Menggunakan Metode Fermentasi

Muafa, Hanifah Ramadhani and Z'Hann, Zenith Christalynne Harmony (2025) Pra Desain Pabrik L-Metionin Dari Gula Kristal Mentah Menggunakan Metode Fermentasi. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Metionin merupakan asam amino esensial yang banyak digunakan dalam industri pakan ternak, farmasi, dan nutraseutikal. Saat ini, Indonesia masih bergantung sepenuhnya pada impor metionin, karena belum memiliki fasilitas produksi dalam negeri. Oleh karena itu, dilakukan pra-desain pabrik L-metionin berbasis fermentasi menggunakan bahan baku gula mentah. Teknologi fermentasi dipilih sebagai alternatif yang lebih ramah lingkungan dibandingkan sintesis kimia, karena dapat menggunakan sumber daya terbarukan dan menghasilkan limbah yang lebih mudah dikelola. Pabrik ini dirancang dengan kapasitas produksi sebesar 1.000 ton per tahun, yang setara dengan 2% kebutuhan impor metionin di Indonesia. Kapasitas ini dipilih untuk mengurangi ketergantungan pada impor secara bertahap, mengoptimalkan efisiensi produksi, serta meminimalkan risiko overproduksi dan ketidakseimbangan pasar. Pra-desain pabrik ini mencakup analisis ketersediaan bahan baku, pemilihan lokasi pabrik, serta aspek teknis dan ekonomi proses fermentasi. Berdasarkan evaluasi, lokasi pabrik yang potensial adalah di Jawa Timur dan Lampung, mengingat ketersediaan bahan baku, infrastruktur industri, serta aksesibilitas pasar. Pemilihan teknologi fermentasi menggunakan Escherichia coli rekayasa genetika, yang mampu menghasilkan L-metionin dengan efisiensi tinggi. Selain itu, aspek lingkungan dan keberlanjutan juga menjadi pertimbangan utama dalam desain ini. Total kapasitas pabrik yang akan didirikan sebesar 1.000 ton/tahun. Kebutuhan bahan baku yang diperlukan dalam produksi pabrik ini adalah gula kristal mentah dengan basis bahan baku sebesar 5.071 ton/tahun, sehingga menghasilkan yield sebesar 37,8%. Setelah dilakukan analisa ekonomi didapatkan bahwa produksi L-metionin memiliki IRR (Internal Rate of Return) sebesar 13,9% yang melampaui WACC (Weighted Average Capital of Cost) 8,7%, didapatkan NPV (Net present Value) > 0. Setelah dilakukan perhitungan, maka diperkirakan pabrik akan mengalami POT (Pay Out Time) 4 tahun setelah produksi dimulai dengan BEP (Break Even Point) sebesar 35%. Dengan adanya pabrik ini, diharapkan Indonesia dapat meningkatkan kemandirian dalam produksi metionin serta membuka peluang ekspor di masa depan.
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Methionine is an essential amino acid widely used in the animal feed, pharmaceutical, and nutraceutical industries. Currently, Indonesia relies entirely on methionine imports due to the absence of domestic production facilities. Therefore, a pre-design study for an L-methionine plant utilizing fermentation technology with raw sugar as the primary feedstock was conducted. Fermentation technology was chosen as an environmentally friendly alternative to chemical synthesis, as it utilizes renewable resources and generates more manageable waste. The plant is designed with a production capacity of 1,000 tons per year, equivalent to 2% of Indonesia's methionine import demand. This capacity was selected to gradually reduce import dependency, optimize production efficiency, and minimize the risks of overproduction and market imbalance.
This plant pre-design includes an analysis of raw material availability, selection of plant location, as well as the technical and economic aspects of the fermentation process. Based on the evaluation, the potential plant locations are East Java and Lampung, considering the availability of raw materials, industrial infrastructure, and market accessibility. The chosen fermentation technology utilizes genetically engineered Escherichia coli, which is capable of producing L-methionine with high efficiency. In addition, environmental and sustainability aspects are also key considerations in this design. The total capacity of the plant to be established is 1,000 tons per year. The raw material required for production is raw crystal sugar, with a raw material basis of 5,071 ton per year, resulting in a yield of 37.8%. Economic analysis shows that L-methionine production has an IRR (Internal Rate of Return) of 13.9%, which exceeds the WACC (Weighted Average Cost of Capital) of 8.7%, and an NPV (Net Present Value) greater than zero. Calculations estimate that the plant will achieve a POT (Pay Out Time) of 4 years after production starts, with a BEP (Break Even Point) of 35%. With the establishment of this plant, it is expected that Indonesia can enhance self-sufficiency in methionine production and open up export opportunities in the future.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Fermentasi, Gula Mentah, GMO Escherichia coli, L-Metionin
Subjects:	T Technology > TP Chemical technology > TP248.3 Biochemical engineering. Bioprocess engineering
Divisions:	Faculty of Industrial Technology and Systems Engineering (INDSYS) > Chemical Engineering > Food Engineering : 41221-(S1) Undergraduate Thesis
Depositing User:	Hanifah Ramadhani Muafa
Date Deposited:	22 Jul 2025 07:39
Last Modified:	22 Jul 2025 07:39
URI:	http://repository.its.ac.id/id/eprint/120562

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