Studi Stabilitas Screen-Printed Carbon Electrode (SPCE) Termodifikasi Nanoselulosa-Polipirol untuk Deteksi Parasetamol pada Kondisi Basa

Hildayanti, Masfufa (2025) Studi Stabilitas Screen-Printed Carbon Electrode (SPCE) Termodifikasi Nanoselulosa-Polipirol untuk Deteksi Parasetamol pada Kondisi Basa. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Penelitian ini membahas stabilitas elektroda Screen-Printed Carbon Electrode (SPCE) yang dimodifikasi dengan nanoselulosa-polipirol untuk deteksi parasetamol pada kondisi basa. Penelitian ini terdiri dari 3 tahap, yaitu (1) sintesis dan karakterisasi nanoselulosa, (2) modifikasi nanoselulosa-polipirol pada permukaan elektroda kerja SPCE, dan (3) menguji kinerja elektroda SPCE termodifikasi nanoselulosa-polipirol untuk deteksi parasetamol pada kondisi basa. Distribusi ukuran partikel nanoselulosa dikarakterisasi menggunakan Particle Size Analyzer (PSA). Morfologi permukaan elektroda kerja SPCE tanpa dan dengan modifikasi dikarakterisasi dengan Scanning Electron Microscope–Energy Dispersive X-Ray (SEM–EDX). Data PSA menunjukkan ukuran nanoselulosa berada pada rentang 280-420 nm. Hasil karakterisasi morfologi menunjukkan bahwa permukaan elektroda kerja SPCE termodifikasi menjadi lebih berpori dan homogen dibandingkan permukaan elektroda kerja tanpa modifikasi. Evaluasi performa elektrokimia dilakukan menggunakan teknik voltametri siklik dalam larutan PBS 0,1 M pH 10 (basa) pada scan rate 0,05 V/s. Hasil pengujian luas permukaan menunjukkan bahwa luas permukaan elektroda meningkat dari 0,082 cm² menjadi 0,115 cm² setelah modifikasi. Berdasarkan persamaan Randels-Sevcik, interaksi antara SPCE termodifikasi nanoselulosa-polipirol dengan parasetamol dikontrol oleh proses difusi. Deteksi parasetamol pada kondisi basa menghasilkan batas deteksi sebesar 0,052 mM dan sensitivitas sebesar 4,590 × 10⁻¹⁰ μA/(mM·cm²) pada rentang konsentrasi 0,1–0,8 mM. Parasetamol dapat dideteksi secara selektif tanpa adanya gangguan dari glukosa, urea, asam askorbat, dan asam urat. Stabilitas sinyal diuji selama 25 kali siklus pengukuran berturut-turut, dan diperoleh nilai Relative Standard Deviation (RSD) sebesar 0,47% untuk puncak oksidasi serta 1,12% untuk puncak reduksi. Nilai tersebut menunjukkan bahwa SPCE termodifikasi nanoselulosa-polipirol memiliki tingkat presisi yang tinggi dibandingkan SPCE tanpa modifikasi dengan RSD pada puncak arus oksidasi sebesar 10,94% dan RSD puncak arus reduksi sebesar 6,90%.
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This study discusses the stability of a Screen-Printed Carbon Electrode (SPCE) modified with nanocellulose-polypyrrole for the detection of paracetamol under alkaline conditions. The study consists of three stages: (1) synthesis and characterization of nanocellulose, (2) modification of SPCE working electrode surface with nanocellulose-polypyrrole, and (3) evaluation of the
performance of the nanocellulose-polypyrrole modified SPCE for paracetamol detection under alkaline conditions. The particle size distribution of nanocellulose was characterized using a Particle Size Analyzer (PSA). The surface morphology of the SPCE working electrode, both
unmodified and modified, was characterized using Scanning Electron Microscope-Energy Dispersive X-Ray (SEM-EDX). PSA data showed that the nanocellulose particle size ranged
between 280–420 nm. Morphological characterization results indicated that the surface of the modified SPCE working electrode became more porous and homogeneous compared to the
unmodified electrode surface. Electrochemical performance was evaluated using cyclic voltammetry in 0.1 M PBS solution at pH 10 (alkaline) with a scan rate of 0.05 V/s. Surface
area testing showed an increase from 0.082 cm² to 0.115 cm² after modification. Based on the Randles–Ševčík equation, the interaction between the nanocellulose-polypyrrole modified SPCE and paracetamol was diffusion-controlled. Paracetamol detection under alkaline conditions yielded a detection limit of 0.052 mM and a sensitivity of 4.590 × 10⁻¹⁰ μA/(mM·cm²) within a concentration range of 0.1–0.8 mM. Paracetamol could be selectively detected without interference from glucose, urea, ascorbic acid, and uric acid. Signal stability was tested over 25 consecutive measurement cycles, resulting in a Relative Standard Deviation (RSD) of 0.47% for the oxidation peak and 1.12% for the reduction peak. These values indicate
that the nanocellulose-polypyrrole modified SPCE has a higher precision level compared to the unmodified SPCE, which showed an oxidation peak current RSD of 10.94% and a reduction peak current RSD of 6.90%.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Kondisi Basa, Nanoselulosa, Parasetamol, Polipirol, Screen-printed carbon electrode (SPCE), Alkaline Condition, Nanocellulose, Paracetamol, Polypyrrole, Screen-printed carbon electrode (SPCE)
Subjects:	Q Science > QD Chemistry > QD1 Oxidation-reduction reaction. Q Science > QD Chemistry > QD115 Electrochemical analysis Q Science > QD Chemistry > QD75.2 Chemistry, Analytic
Divisions:	Faculty of Science and Data Analytics (SCIENTICS) > Chemistry > 47201-(S1) Undergraduate Thesis
Depositing User:	Masfufa Hildayanti
Date Deposited:	04 Aug 2025 04:45
Last Modified:	04 Aug 2025 04:45
URI:	http://repository.its.ac.id/id/eprint/125928

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