Sintesis Ligan Turunan Hidrazon dan Kompleks Cu(II)-2-hidroksibenziliden-4-metilbenzohidrazida sebagai Agen Antibakteri

Kartikasari, Asvianti (2025) Sintesis Ligan Turunan Hidrazon dan Kompleks Cu(II)-2-hidroksibenziliden-4-metilbenzohidrazida sebagai Agen Antibakteri. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Meningkatnya resistensi bakteri terhadap antibiotik konvensional mendorong pengembangan senyawa antibakteri berbasis kompleks logam transisi. Pada penelitian ini ligan 2-hidroksibenziliden-4-metilbenzohidrazida dan kompleks Cu(II)-2- hidroksibenziliden-4-metilbenzohidrazida telah berhasil disintesis dengan rendemen sebesar 92,5% dan 68,86%. Dikarakterisasi menggunakan spektroskopi FTIR, UV-Vis, analisis termogravimetri (TGA), MS dan XRD Powder. Spektrum FTIR menunjukkan bahwa kompleks berada dalam bentuk tautomer keto, dengan pita serapan khas pada 470 cm⁻¹ (ikatan koordinasi Cu–N) serta 528 cm⁻¹ (ikatan koordinasi Cu–O), menandakan terjadinya koordinasi antara logam Cu(II) dan ligan melalui atom nitrogen dan oksigen. Spektrum UV-Vis memperlihatkan pergeseran panjang gelombang dari 323 nm (ligan bebas) menjadi 382 nm pada kompleks, yang mengindikasikan adanya proses transfer elektron dari logam ke ligan (Metal-to-Ligand Charge Transfer/MLCT). Data TGA menunjukkan bahwa kompleks Cu(II)-2-hidroksibenziliden-4-metilbenzohidrazida terdekomposisi pada suhu 100-180oC yang mengonfirmasi stabilitas termal kompleks Cu(II)-2-hidroksibenziliden-4-metilbenzohidrazida serta rasio logam:ligan sebesar 1:1. Hasil XRD Powder menunjukkan pola difraksi kompleks merupakan sistem monoklinik. Uji aktivitas antibakteri menggunakan metode difusi cakram terhadap bakteri Staphylococcus aureus dan Escherichia coli menunjukkan bahwa ligan memiliki zona inhibisi sebesar 0 mm dan 9,0 ± 0,0 mm, sedangkan kompleks menunjukkan zona inhibisi sebesar 8,85 ± 0,65 mm dan 12,2 ± 0,7 mm terhadap masing-masing bakteri. Kompleks Cu(II)-2-hidroksibenziliden-4-metilbenzohidrazida menunjukkan aktivitas antibakteri yang baik, khususnya terhadap bakteri E. coli.
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The increasing resistance of bacteria to conventional antibiotics has driven the development of antibacterial compounds based on transition metal complexes. In this study, the ligand 2-hydroxybenzylidene-4-methylbenzohydrazide and the Cu(II)-2-hydroxybenzylidene-4-methylbenzohydrazide complex were successfully synthesized with a yield of 92.5%. and 68.86%. Characterization was performed using FTIR spectroscopy, UV-Vis spectroscopy, thermogravimetric analysis (TGA), MS, and XRD powder analysis. The FTIR spectrum indicates that the complex is in the keto tautomer form, with characteristic absorption bands at 470 cm⁻¹ (Cu–N coordination bond) and 528 cm⁻¹ (Cu–O coordination bond), indicating coordination between the Cu(II) metal and the ligand via nitrogen and oxygen atoms. The UV-Vis spectrum shows a shift in wavelength from 323 nm (free ligand) to 382 nm in the complex, indicating the occurrence of electron transfer from the metal to the ligand (Metal-to-Ligand Charge Transfer/MLCT). TGA data show that the Cu(II)-2-hydroxybenzylidene-4-methylbenzohydrazide complex decomposes at temperatures between 100–180°C, confirming the thermal stability of the Cu(II)-2-hydroxybenzylidene-4-methylbenzohydrazide complex and a metal:ligand ratio of 1:1. The XRD Powder results show the diffraction pattern of the complex using the monoclinic system. Antibacterial activity testing using the disk diffusion method against Staphylococcus aureus and Escherichia coli bacteria showed that the ligand had inhibition zones of 0 mm and 9.0 ± 0.0 mm, respectively, while the complex exhibited inhibition zones of 8.85 ± 0.65 mm and 12.2 ± 0.7 mm against each bacterium. The Cu(II)-2-hydroxybenzylidene-4-methylbenzohydrazide complex exhibits good antibacterial activity, particularly against E. coli bacteria.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Antibakteri, Hidrazon, Kompleks, Tembaga(II), Sintesis. Antibacterial, Complex, Copper(II), Hydrazone, Synthesis.
Subjects:	Q Science > QD Chemistry > QD251.2 Chemistry, Organic. Biochemistry Q Science > QD Chemistry > QD63 Extraction
Divisions:	Faculty of Science and Data Analytics (SCIENTICS) > Chemistry > 47201-(S1) Undergraduate Thesis
Depositing User:	Asvianti Kartikasari
Date Deposited:	05 Aug 2025 01:37
Last Modified:	05 Aug 2025 01:37
URI:	http://repository.its.ac.id/id/eprint/126944

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