Rosyadi, Maghfiroh Ila Nur (2025) Evaluasi Stabilitas Ukuran Obat Nano Gartanin Dengan Pelapisan Gelatin Ikan Kakap (Lutjanidae) dan Taut Silang Glutaraldehida. Other thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Gartanin merupakan senyawa turunan xanton yang terdapat dalam kulit buah manggis (Garcinia mangostana L.) dan memiliki aktivitas anti-kanker, anti-proliferatif, serta pro-apoptosis. Gartanin dalam bentuk nano menjadi pendekatan yang menjanjikan dalam sistem penghantaran obat kanker. Namun, stabilitas obat nano gartanin dalam medium biologis masih menjadi tantangan karena rentan mengalami agregasi. Penelitian ini bertujuan untuk meningkatkan stabilitas obat nano gartanin dengan pelapisan menggunakan gelatin ikan kakap (Lutjanidae), biomaterial alami yang bersifat biokompatibel, serta taut silang dengan glutaraldehida untuk memperkuat struktur pelapisan. Penelitian dilakukan melalui skrining pelarut, skrining variasi konsentrasi glutaraldehida, perbandingan obat nano gartanin termodifikasi dan uji stabilitas pH. Ukuran partikel dikarakterisasi dengan Particle Size Analyzer (PSA), sedangkan morfologi partikel diamati dengan Field Emission Scanning Electron Microscope (FE-SEM). Hasil penelitian menunjukkan bahwa obat nano gartanin dengan pelapisan gelatin ikan kakap dan taut silang glutaraldehida 0,04% menghasilkan ukuran partikel paling stabil dan mendekati rentang ideal efek Enhanced Permeability and Retention (EPR). Penambahan pelapisan dan taut silang mampu mempertahankan morfologi obat nano gartanin yang seragam dan mencegah agregasi baik dalam kondisi pH fisiologis maupun asam. Dengan demikian, sistem ini memiliki potensi untuk dikembangkan lebih lanjut sebagai penghantaran obat kanker berbasis nano.
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Gartanin is a xanthone derivative compound found in the rind of mangosteen (Garcinia mangostana L.) and has anti-cancer, anti-proliferative and pro-apoptotic activities. Gartanin in nano form is a promising approach in cancer drug delivery systems. However, the stability of gartanin nano drugs in biological media remains a challenge because it is susceptible to aggregation. This study aims to improve the stability of gartanin nano drugs by coating them using snapper fish gelatin (Lutjanidae), a natural biomaterial that is biocompatible and cross-linking with glutaraldehyde to strengthen the coating structure. The study was conducted through solvent screening, screening variations in glutaraldehyde concentration, comparison of modified gartanin nano drugs and pH stability tests. Particle size was characterized by a Particle Size Analyzer (PSA), while particle morphology was observed by a Field Emission Scanning Electron Microscope (FE-SEM). The results showed that gartanin nanodrugs coated with snapper gelatin and 0.04% glutaraldehyde cross-linking produced the most stable particle size and approached the ideal range of Enhanced Permeability and Retention (EPR) effects. The addition of coating and cross-linking was able to maintain the uniform morphology of gartanin nanodrugs and prevent aggregation in both physiological and acidic pH conditions. Thus, this system has the potential to be further developed as a nano-based cancer drug delivery system.
| Item Type: | Thesis (Other) |
|---|---|
| Uncontrolled Keywords: | Efek EPR, Gartanin, Gelatin Ikan Kakap, Glutaraldehida, Nanopartikel. EPR Effect, Gartanin, Glutaraldehyde, Nanoparticles, Snapper Fish Gelatin |
| Subjects: | Q Science > QD Chemistry > QD75.2 Chemistry, Analytic |
| Divisions: | Faculty of Science and Data Analytics (SCIENTICS) > Chemistry > 47201-(S1) Undergraduate Thesis |
| Depositing User: | Maghfiroh Ila Nur Rosyadi |
| Date Deposited: | 05 Aug 2025 04:16 |
| Last Modified: | 05 Aug 2025 04:16 |
| URI: | http://repository.its.ac.id/id/eprint/127384 |
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