Evaluasi Dosis Pada Variasi Fraksinasi Perawatan Kanker Servik Teknik 3D-CRT Menggunakan Fantom Antropomorfik

Fatinah, Tri Tamimah Mulya (2025) Evaluasi Dosis Pada Variasi Fraksinasi Perawatan Kanker Servik Teknik 3D-CRT Menggunakan Fantom Antropomorfik. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Penelitian ini bertujuan mengevaluasi distribusi dosis radiasi pada organ-at-risk (OAR) yang berada pada area di dalam penyinaran (in-field) serta area di luar lapangan (out‑of‑field) menggunakan fantom antropomorfik, serta menganalisis dampak teknik fraksinasi, hiperfraksinasi, hipofraksinasi, dan konvensional terhadap Normal Tissue Complication Probability (NTCP). Verifikasi dosis dengan film Gafchromic EBT4 menunjukkan bahwa distribusi dosis terhadap OAR in‑field stabil dan deviasinya masih di bawah ambang toleransi 3–5%, menegaskan akurasi TPS dalam memodelkan dosis utama. Sebaliknya, dosis pada organ di luar medan menunjukkan underestimation TPS signifikan. Secara radiobiologis, analisis NTCP menunjukkan bahwa hipofraksinasi menghasilkan nilai NTCP lebih rendah pada kandung kemih dan rektum dibandingkan skema konvensional dan hiperfraksinasi, berkat distribusi dosis yang lebih konformal dan waktu total pengerjaan yang lebih singkat. Namun, untuk organ di luar lapangan, nilai NTCP justru tinggi pada hipofraksinasi, akibat dosis scatter dan leakage yang lebih besar tetapi tidak termodel oleh TPS.
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This study aimed to evaluate the radiation dose distribution to organs-at-risk (OAR) located within the irradiation field (in-field) and out-of-field areas using anthropomorphic phantoms, and to analyze the impact of fractionation, hyperfractionation, hypofractionation, and conventional techniques on the Normal Tissue Complication Probability (NTCP). Dose verification using Gafchromic EBT4 film showed that the dose distribution to in-field OARs was stable and its deviation remained below the tolerance threshold of 3–5%, confirming the accuracy of TPS in modeling the primary dose. In contrast, the dose to out-of-field organs showed a significant TPS underestimation. Radiobiologically, NTCP analysis showed that hypofractionation resulted in lower NTCP values in the bladder and rectum compared to conventional and hyperfractionation schemes, due to a more conformal dose distribution and shorter total processing time. However, for out-of-field organs, NTCP values were higher in hypofractionation, due to larger scatter and leakage doses not modeled by TPS.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Fraksinasi, In Field, Out of field, NTCP.
Subjects:	Q Science > QC Physics Q Science > QC Physics > QC795.5 Radioactivity and radioactive Instruments and apparatus (General)
Divisions:	Faculty of Science and Data Analytics (SCIENTICS) > Physics > 45201-(S1) Undergraduate Thesis
Depositing User:	Tri Tamimah Mulya Fatinah
Date Deposited:	07 Aug 2025 03:11
Last Modified:	07 Aug 2025 03:11
URI:	http://repository.its.ac.id/id/eprint/127898

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