Ningtyas, Agnes Rachmah and Sriatien, Sriatien (2026) Hidrogel Komposit K-Karagenan / Polyetylene Glycol / Zinc Oxide Injeksi untuk Preservasi Alveolar Ridge dengan Degradasi Terkontrol dan Sifat Antibakteri. Other thesis, Institut Teknologi Sepuluh Nopember.
![[thumbnail of 2041221065-Undergraduate_Thesis.pdf]](http://repository.its.ac.id/style/images/fileicons/text.png) |
Text
2041221065-Undergraduate_Thesis.pdf - Accepted Version Restricted to Repository staff only Download (5MB) | Request a copy |
Abstract
Resorpsi tulang alveolar setelah pencabutan gigi dapat mencapai 40–60% dalam enam bulan pertama, sehingga menurunkan stabilitas implan dan keberhasilan rehabilitasi jangka panjang. Hidrogel injectable merupakan biomaterial yang menjanjikan untuk aplikasi alveolar ridge preservation (ARP) karena mampu mengisi bentuk soket secara optimal dan menyerupai matriks ekstraseluler. Penelitian ini bertujuan mensintesis komposit hidrogel κ-carrageenan/polyethylene glycol/zinc oxide (CG/PEG/ZnO) menggunakan metode gelasi ionik dengan KCl, menentukan formulasi terbaik, mengkarakterisasi sifat fisikokimia dan morfologinya, serta mengevaluasi karakteristik fungsionalnya sebagai injectable scaffold. Karakterisasi dilakukan menggunakan Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy–Energy Dispersive X-ray Spectroscopy (SEM–EDX), X-ray Diffraction (XRD), dan Thermogravimetric Analysis (TGA), sedangkan karakteristik fungsional dievaluasi melalui pengujian swelling ratio, degradasi, dan injectability. Hasil penelitian menunjukkan bahwa komposit hidrogel CG/PEG/ZnO berhasil disintesis dengan metode gelasi ionik menggunakan KCl. Formulasi CG:PEG 4:1:0,5 ZnO menghasilkan performa terbaik berdasarkan keseimbangan integritas struktur, stabilitas termal, ketahanan degradasi, dan kemudahan aplikasi. Analisis FTIR, SEM–EDX, XRD, dan TGA mengonfirmasi terbentuknya komposit hidrogel dengan jaringan tiga dimensi berpori, distribusi ZnO yang baik dalam matriks, derajat kristalinitas sebesar 91,24%, serta stabilitas termal yang tinggi. Selain itu, hidrogel menunjukkan swelling yang terkendali, laju degradasi sekitar 20% dalam 7 hari, serta injectability yang baik dengan sifat shear-thinning, mampu diekstrusi secara halus tanpa menyumbat jarum. Hasil tersebut menunjukkan bahwa komposit hidrogel CG/PEG/ZnO memiliki karakteristik fisikokimia dan fungsional yang mendukung potensinya sebagai injectable scaffold untuk aplikasi alveolar ridge preservation.
======================================================================================================================================
Alveolar ridge resorption following tooth extraction may reach 40–60% within the first six months, compromising implant stability and long-term clinical outcomes. Injectable hydrogels have emerged as promising scaffolds for alveolar ridge preservation (ARP) because of their ability to conform to irregular socket geometry while mimicking the extracellular matrix. This study aimed to synthesize an injectable κ-carrageenan/polyethylene glycol/zinc oxide (CG/PEG/ZnO) composite hydrogel using KCl-mediated ionic gelation, determine the optimum formulation, characterize its physicochemical and morphological properties, and evaluate its functional performance for ARP applications. The hydrogels were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy–Energy Dispersive X-ray Spectroscopy (SEM–EDX), X-ray Diffraction (XRD), and Thermogravimetric Analysis (TGA), followed by swelling, degradation, and injectability tests. The results demonstrated the successful formation of CG/PEG/ZnO composite hydrogels with interconnected three-dimensional porous structures, homogeneous ZnO distribution, high crystallinity (91.24%), and enhanced thermal stability. Among all formulations, CG:PEG 4:1:0,5 ZnO exhibited the most balanced performance, providing superior structural integrity, thermal stability, controlled swelling, approximately 20% degradation after 7 days, and excellent injectability characterized by shear-thinning behavior, smooth extrusion, and no needle blockage. These findings indicate that the developed CG/PEG/ZnO composite hydrogel possesses suitable physicochemical and functional characteristics, highlighting its potential as an injectable scaffold for alveolar ridge preservation.
| Item Type: | Thesis (Other) |
|---|---|
| Uncontrolled Keywords: | Carageenan, Alveolar Ridge Preservation, Bio-Scaffold, Biodegradable, Injectable Hidrogel =========================================================== Carageenan; Alveolar Ridge Preservation; Bio-Scaffold; Biodegradable; Injectable Hydrogel |
| Subjects: | T Technology > TP Chemical technology > TP1140 Polymers T Technology > TP Chemical technology > TP248 Nanogels. Nanoparticles. |
| Divisions: | Faculty of Vocational > 24305-Industrial Chemical Engineering |
| Depositing User: | Agnes Rachmah Ningtyas |
| Date Deposited: | 25 Jul 2026 04:29 |
| Last Modified: | 25 Jul 2026 04:29 |
| URI: | http://repository.its.ac.id/id/eprint/137593 |
Actions (login required)
 |
View Item |