Ardianto, Gilang Rifki (2026) Sintesis dan Uji Aktivitas Antibakteri Kompleks Zn(II) dengan Ligan N-(2-(2-hidroksibenzoil)hidrazin-1-karbonotioil)furan-2-karboksamida dan N-(2-(2-hidroksibenzoil)hidrazin-1-karbonotioil)nikotinamida. Other thesis, Institut Teknologi Sepuluh Nopember.
![[thumbnail of 5004221079-Undergraduate_Thesis.pdf]](http://repository.its.ac.id/style/images/fileicons/text.png) |
Text
5004221079-Undergraduate_Thesis.pdf Restricted to Repository staff only Download (5MB) | Request a copy |
Abstract
Krisis kesehatan global yang dipicu oleh peningkatan resistensi antimikroba mendorong pengembangan agen antibakteri baru yang lebih efektif. Salah satu strateginya yaitu memanfaatkan kompleks Zn(II) dengan ligan tiosemikarbazida tersubstitusi cincin heterosiklik dan aromatik. Logam Zn merupakan salah satu mikronutrien esensial yang penting dan bermanfaat bagi tubuh, serta memiliki kemampuan membentuk kompleks yang stabil untuk meningkatkan aktivitas antibakteri. Penelitian ini bertujuan mensintesis kompleks Zn(II) dengan ligan N-(2-(2-hidroksibenzoil)hidrazin-1-karbonotioil)furan-2-karboksamida (H4L1) dan N-(2-(2-hidroksibenzoil)hidrazin-1-karbonotioil)nikotinamida (H4L2) serta mengevaluasi aktivitas antibakterinya terhadap bakteri Escherichia coli dan Staphylococcus aureus. Ligan disintesis melalui metode refluks dengan mereaksikan KSCN, 2-hidroksibenzohidrazida, dan 2-furoil klorida/nikotinoil klorida hidroklorida. Sementara itu, kompleks Zn(II) disintesis melalui metode refluks dengan mereaksikan masing-masing ligan terhadap prekursor Zn(II) (Zn(C2H3O2)2·2H2O atau ZnSO4·7H2O) pada pH 6. Hasil sintesis diperoleh ligan H4L1 dan H4L2 berupa padatan putih dengan rendemen secara berturut-turut sebesar 53,26 dan 23,41%. Kompleks Zn(II)-HL1 yang diperoleh berwarna kuning dan kompleks Zn(II)-H4L2 berwarna putih dengan rendemen secara berturut-turut 83,44 dan 85,91%. Berdasarkan karakterisasi FTIR, UV-Vis, AAS, dan CHNS/O, prediksi formula kompleks secara berturut-turut adalah [Zn3(HL1)2(H2O)2] dan [Zn2(H4L2)(SO4)2]·3H2O. Karakterisasi Powder-XRD menunjukkan kedua kompleks bersifat polikristalin dan tergolong nanokristalin. Aktivitas antibakteri menunjukkan bahwa kompleks Zn(II)-HL1 memiliki zona hambat yang lebih rendah dari ligan bebasnya karena struktur kompleks yang kaku dan besar sehingga membatasi kemampuannya melewati membran bakteri. Sementara itu, kompleks Zn(II)-H4L2 memiliki zona hambat yang lebih tinggi dari ligan bebasnya yang disebabkan oleh adanya efek khelat pada ion logam sehingga meningkatkan sifat lipofilisitas senyawa untuk berpenetrasi ke dalam sel bakteri.
============================================================================================================================================
The global health crisis triggered by the increasing antimicrobial resistance drives the development of new and more effective antibacterial agents. One of the strategies is through the synthesis of Zn(II) complexes with thiosemicarbazide ligands substituted by heterocyclic and aromatic rings. Zinc is an essential, beneficial micronutrient capable of forming stable complexes to enhance antibacterial activity. This study aims to synthesize Zn(II) complexes with N-(2-(2-hydroxybenzoyl)hydrazine-1-carbonothioyl)furan-2-carboxamide (H4L1) and N-(2-(2-hydroxybenzoyl)hydrazine-1-carbonothioyl)nicotinamide (H4L2) ligands and evaluate their antibacterial activities against Escherichia coli and Staphylococcus aureus. Ligands were synthesized via reflux by reacting KSCN, 2-hydroxybenzohydrazide, and 2-furoyl chloride/nicotinoyl chloride hydrochloride. Meanwhile, Zn(II) complexes were synthesized by refluxing each ligand with a Zn(II) precursor, namely Zn(C2H3O2)2·2H2O or ZnSO₄·7H2O, at pH 6. White H4L1 and H4L2 ligands were obtained with yields of 53.26% and 23.41%, respectively. The yellow Zn(II)-HL1 complex and white Zn(II)-H4L2 complex were obtained with yields of 83.44% and 85.91%, respectively. Based on FTIR, UV-Vis, AAS, and CHNS/O characterizations, the predicted formulas of the complexes were [Zn3(HL1)2(H2O)₂] and [Zn2(H4L2)(SO4)2]·3H2O, respectively. Powder-XRD characterizations showed that both complexes were polycrystalline and classified as nanocrystalline. Antibacterial assays showed the Zn(II)-HL1 complex has a lower inhibition zone than its free ligand due to its rigid and bulky structure, limiting diffusion through bacterial membranes. Conversely, the Zn(II)-H4L2 complex exhibits a higher inhibition zone than its free ligand due to the chelation effect on the metal ion, which increases lipophilicity for better penetration into bacterial cells.
| Item Type: | Thesis (Other) |
|---|---|
| Uncontrolled Keywords: | Antibakteri, Kompleks Zn(II), Sintesis, Tiosemikarbazida. Antibacterial, Synthesis, Thiosemicarbazide, Zn(II) Complex. |
| Subjects: | Q Science Q Science > QD Chemistry Q Science > QD Chemistry > QD471 Chemical compounds - Structure and formulas |
| Divisions: | Faculty of Science and Data Analytics (SCIENTICS) > Chemistry > 47201-(S1) Undergraduate Thesis |
| Depositing User: | Gilang Rifki Ardianto |
| Date Deposited: | 31 Jul 2026 02:26 |
| Last Modified: | 31 Jul 2026 02:26 |
| URI: | http://repository.its.ac.id/id/eprint/140846 |
Actions (login required)
 |
View Item |