Maghfiroh, Reyza Fadly (2026) Sintesis Kompleks Kobal(II) Berbasis Ligan Furan-2-karboksamida-tiosemikarbazida dan Evaluasi Penghambatan Terhadap Mycobacterium tuberculosis. Masters thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Tuberkulosis, penyakit yang disebabkan oleh Mycobacterium tuberculosis masih menjadi salah satu ancaman kesehatan global sehingga diperlukan pengembangan kandidat obat baru yang lebih efektif. Salah satu pendekatan yang berpotensi dikembangkan adalah pemanfaatan kompleks logam berbasis kobal(II) karena sifat koordinasi dan aktivitas biologinya. Penelitian ini bertujuan menyintesis, mengkarakterisasi, serta mengevaluasi aktivitas antibakteri, antituberkulosis, dan sifat farmakokinetik (in silico) kompleks kobal(II) berbasis ligan furan-2-karboksamida-tiosemikarbazida. Ligan H3L1 (14) dan H4L2 (15) disintesis melalui reaksi antara 2-furoil klorida, KSCN, dan turunan benzohidrazida dengan rendemen masing-masing sebesar 58,7% dan 53,44%. Selanjutnya, kompleks Co(II)-HL1 dan Co(II)-H2L2 disintesis dengan metode solvotermal menghasilkan rendemen berturut-turut sebesar 86,67% dan 74,43%. Karakterisasi menggunakan FTIR, UV-Vis, CHNS/O, AAS, dan P-XRD mengonfirmasi terbentuknya kompleks kobal(II) dengan notasi Na2[Co8(HL1)2Cl14].4DMF dan Na[Co3(H2L2)2(H2O)3Cl3]. Hasil uji aktivitas antibakteri menunjukkan bahwa ligan dan kompleks memiliki aktivitas yang selektif terhadap bakteri Gram positif dengan kategori aktivitas penghambatan moderat, kecuali ligan H4L2 (15) yang menunjukkan aktivitas penghambatan sangat baik terhadap Escherichia coli. Seluruh senyawa juga menunjukkan aktivitas antituberkulosis pada kategori moderat, dengan kompleks Co(II)-HL1 memiliki aktivitas terbaik terhadap M. tuberculosis dengan nilai MIC sebesar 250 μg/mL. Prediksi ADMET menunjukkan bahwa ligan H3L1 (14) dan H4L2 (15) memenuhi kriteria Lipinski's Rule of Five serta diprediksi memiliki adsorpsi oral dan permeabilitas membran yang baik. Hasil penelitian ini menunjukkan bahwa kompleks kobal(II) berbasis furan-2-karboksamida-tiosemikarbazida, khususnya Co(II)-HL1, berpotensi dikembangkan lebih lanjut sebagai kandidat agen antituberkulosis.
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Tuberculosis, caused by Mycobacterium tuberculosis, remains a major global health challange, highlighting the urgent need for the development of novel and more effective therapeutic agents. Cobalt-based metal complexes have attracted considerable attention as potential drug candidates owing to their versatile coordination chemistry and promising biological activities. This study aimed to synthesize, characterize, and evaluate the antibacterial, antituberculosis, and in silico pharmacokinetic properties of Co(II) complexes derived from furan-2-carboxamide-thiosemicarbazide ligands. The ligands H3L1 (14) and H4L2 (15) were synthesized by reaction of 2-furoyl chloride, KSCN, and benzohydrazide derivatives, affording yields of 58.74% and 53.44%, respectively. Subsequently, the Co(II)-HL1 and Co(II)-H2L2 complexes were prepared using solvothermal method with yields of 86.67% and 74.47%, respectively. Structural characterization by FTIR, UV-Vis, CHNS/O elemental analysis, AAS, and P-XRD confirmed the formation of the proposed Co(II) complexes, identified as Na2[Co8(HL1)2Cl14].4DMF and Na[Co3(H2L2)2(H2O)3Cl3]. Biological evaluation demonstrated that the ligands and complexes exhibited selective antibacterial activity against Gram-positive bacteria with moderate inhibitory effects, except for H4L2 (15), which showed excellent activity against Escherichia coli. All synthesized compounds displayed moderate antitubercular activity, with Co(II)-HL1 exhibiting the highest potency against M. tuberculosis with a minimum inhibitory concentration (MIC) of 250 μg/mL. ADMET prediction revealed that H3L1 (14) and H4L2 (15) satisfy Lipinski's Rule of Five and possess favorable oral absorption and membrane permeability. These findings suggest that Co(II) complexes based on furan-2-carboxamide-thiosemicarbazide, particularly, Co(II)-HL1, represent promising candidates for further development as antituberculosis agents.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Kobal(II), Kompleks, Furan-2-karboksamida, Tiosemikarbazida, Tuberkulosis, Cobalt(II), Complexes, Furan-2-carboxamide, Thiosemicarbazide, Tuberculosis |
| Subjects: | Q Science > QD Chemistry > QD471 Chemical compounds - Structure and formulas |
| Divisions: | Faculty of Science and Data Analytics (SCIENTICS) > Chemistry > 47101-(S2) Master Thesis |
| Depositing User: | Reyza Fadly Maghfiroh |
| Date Deposited: | 04 Aug 2026 08:05 |
| Last Modified: | 04 Aug 2026 08:05 |
| URI: | http://repository.its.ac.id/id/eprint/143450 |
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