Uji Aktivitas Antimalaria Senyawa Biflavonoid GB-1a Dan Morelloflavon Kayu Akar Garcinia xanthochymus (Buran)

Wahyuningsih, Sri (2009) Uji Aktivitas Antimalaria Senyawa Biflavonoid GB-1a Dan Morelloflavon Kayu Akar Garcinia xanthochymus (Buran). Masters thesis, Institut Teknologi Sepuluh November.

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Abstract

Pada penelitian kandungan kimiawi kayu akar Garcinia xanthochymus (Buran) dari Kebun Raya Bogor, Jawa Barat melalui proses isolasi dan elusidasi struktur dihasilkan 2 senyawa biflavonoid yang telah ditemukan sebelumnya, yakni GB-1a (1) dan morelloflavon (2). Isolasi dilakukan dengan maserasi dan dilanjutkan proses fraksinasi kromatografi cair vakum (KCV) dan Kromatografi Kolom Gravitasi (KKG), serta proses pemurnian dengan Kromatografi Lapis Tipis preparatif (KLTp) dan Kromatotron. Elusidasi struktur dilakukan dengan menggunakan data-data spektroskopi meliputi spektroskopi UV, IR, ¹H-NMR, dan ¹³C-NMR. Kedua isolat diuji daya hambatnya terhadap pertumbuhan strain Plasmodium falciparum sensitif klorokuin. IC₅₀ senyawa (1) dan (2) berturut-turut senilai 0,34 µg/mL dan 0,01 µg/mL.
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Chemical investigation of the roots of Garcinia xanthochymus (Buran) from Bogor Botanical Garden, West Java has resulted in the isolation and structure elucidation of known biflavonoids, GB-1a (1) and morelloflavone (2). Their structures were established on the basis of analysis of spectroscopic evidence (UV, IR, ¹H-NMR and ¹³C-NMR spectroscopy). The antimalarial activity of these compounds against chloroquine-sensitive Plasmodium falciparum were also evaluated. These biflavonoids (1) and (2) showed inhibitory effects of the growth of its parasites with IC₅₀ values 0,34 µg/mL and 0,01 µg/mL.

Item Type:	Thesis (Masters)
Additional Information:	RTKi 583.624 Sri u
Uncontrolled Keywords:	Garcinia xanthochymus, antimalaria, biflavonoid, Plasmodium falciparum
Subjects:	Q Science > QD Chemistry > QD251.2 Chemistry, Organic. Biochemistry
Divisions:	Faculty of Mathematics and Science > Chemistry > 47101-(S2) Master Thesis
Depositing User:	magang .
Date Deposited:	05 Oct 2026 01:36
Last Modified:	05 Oct 2026 01:36
URI:	http://repository.its.ac.id/id/eprint/145222

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