REAKSI ISATIN DENGAN 4-BROMOANILINA DAN ISATIN DENGAN 3-BROMOANILINA

SAGITA, DEVIN ARI (2014) REAKSI ISATIN DENGAN 4-BROMOANILINA DAN ISATIN DENGAN 3-BROMOANILINA. Undergraduate thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Reaksi isatin dengan 2,5-dimetoksianilina dengan
perbandingan 1:1 telah dikaji guna memperoleh 3-(2,5-
dimetoksifenilimino)-1,3-dihidroindol-2-on, tapi yang diperoleh
adalah 3,3-bis(4-amino-2,5-dimetoksifenil)-1,3-dihidroindol-2-on
sehingga dilakukan pengkajian lagi terhadap reaksi isatin dengan
anilina tersubitusi, bertujuan untuk memperoleh imina. Penelitian
yang dilaksanakan bertujuan untuk mengkaji reaksi isatin dengan
4-bromoanilina maupun 3-bromoanilina. Reaksi isatin dengan 4-
bromoanilina, diperoleh 3-(4-bromofenilimino)-1,3-dihidroindol-
2-on dengan rendemen 89% (metoda A), 83% (metoda B) dan
94% (metoda C). Reaksi isatin dengan 3-bromoanilina diperoleh
3-(3-bromofenilimino)-1,3-dihidroindol-2-on dengan rendemen
50% (metoda A) dan 20% (metoda B). Endapan hasil reaksi yang
didapat berupa padatan kuning, yang selanjutnya diidentifikasi
menggunakan LC MS-ESI dan spectrometer NMR.

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The reaction of isatin with 2,5-dimetoksianiline with a ratio of
1:1 had been studied in order to obtain 3-(2,5-
dimethoxyphenylimino)-1,3-dihydroindole-2-one, but obtained
was 3,3-bis(4-amino-2,5-dimethoxyphenyl)-1,3-dihydroindole-2-
one assessment that was done again to react isatin with subtituted
aniline, aiming to obtain imine. In this study, the reaction of isatin
with 4-bromoaniline and 3-bromoaniline was done. The reaction
of isatin with 4-bromoaniline, obtained 3 (4-bromophenylimino)-
1,3-dihydroindole-2-one with the deposition reaction proceeds by
89% (method A), 83% (method B ) and 94% (method C). The
reaction of isatin with 3-bromoaniline, obtained 3-(3-
bromophenylimino)-1,3-dihydroindole-2-one with the deposition
reaction yield of 50% (method A) and 20% (method B). The
precipitate of reaction product was obtained in the form of a
yellow solid, which was subsequently identified using LCMS-ESI
and NMR spectometry.

Item Type:	Thesis (Undergraduate)
Additional Information:	RSKi 572.528 Sag r
Uncontrolled Keywords:	isatin, 3-bromoanilina, 4-bromoanilia, imina
Subjects:	Q Science Q Science > QD Chemistry
Divisions:	Faculty of Mathematics and Science > Chemistry > 47201-(S1) Undergraduate Thesis
Depositing User:	Mr. Tondo Indra Nyata
Date Deposited:	13 Jan 2017 07:26
Last Modified:	13 Jan 2017 07:26
URI:	http://repository.its.ac.id/id/eprint/1550

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