Riyani, Febri Indah (2019) Sintesis Tiga Turunan 5-Nitroindola. Other thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Kanker merupakan masalah kesehatan yang menjadi penyebab utama morbiditas dan mortalitas terbesar di dunia, tetapi pengobatan kanker hingga saat ini masih terdapat kekurangan. Studi literatur yang dilakukan mendapatkan bahwa trisindolina memiliki bioaktivitas antikanker yang dapat dimanfaatkan sebagai lead compound senyawa-senyawa antikanker. Penelitian yang dilakukan berhasil mendapatkan tiga trisindolina baru turunan 5-nitroindola (6) yaitu 3,3’-di(5-nitroindol-3-il)-5,7-dibromoindolin-2-on (5a), 3,3’-di(5-nitroindol-3-il)-7-bromoindolin-2-on (5b), dan 3,3’-di(5-nitroindol-3-il)-5-bromoindolin-2-on (5c). Reaksi 5-nitroindola dengan 5,7-dibromoisatin (7a), 7-bromoisatin (7b), serta 5-bromoisatin (7c) dalam metanol pada kondisi asam masing-masing diperoleh trisindolina (5a-c) dengan rendemen masing-masing 90%, 85%, dan 88%. Identifikasi struktur trisindolina (5a-c) dilakukan dengan spektrometer massa resolusi tinggi, NMR (1H, 13C), dan FTIR. ==============================================================================================================================
Cancer is a health problem that is the main cause of the world's largest morbidity and mortality, but cancer treatment is still lacking. The literature study conducted found that trisindolina has anticancer bioactivity which can be used as a lead compound for anticancer compounds. The research was successful in obtaining three new 5-nitroindole (6) trisindolines (3,3'-di (5-nitroindol-3-il)-5,7-dibromoindolin-2-on (5a), 3,3'- di (5-nitroindol-3-il)-7-bromoindolin-2-on (5b), and 3,3'-di (5-nitroindol-3-il)-5-bromo indolin-2-on (5c). The 5-nitroindole reaction with 5,7-dibromoisatin (7a), 7-bromoisatin (7b),and 5-bromoisatin (7c) in methanol under acidic conditions was obtained by trisindolina (5a-c) with a yield of 90%, 85%, and 88%. Identification of the structure of trisindolina (5a-c) was carried out with a high-resolution mass spectrometer, NMR (1H, 13C), and FTIR.
| Item Type: | Thesis (Other) |
|---|---|
| Additional Information: | RSKi 547.28 Riy s-1 2019 |
| Uncontrolled Keywords: | Sintesis, anti kanker, turunan 5-nitroindola, trisindolina |
| Subjects: | Q Science > QD Chemistry > QD251.2 Chemistry, Organic. Biochemistry |
| Divisions: | Faculty of Natural Science > Chemistry > 47201-(S1) Undergraduate Thesis |
| Depositing User: | Febri Indah Riyani |
| Date Deposited: | 11 Jan 2023 06:28 |
| Last Modified: | 11 Jan 2023 06:28 |
| URI: | http://repository.its.ac.id/id/eprint/64295 |
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