Elanda, Febby Fedika (2019) Kapsul Berbahan Dasar Kitosan Larut Air dari Kulit Udang. Other thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Cangkang kapsul telah berhasil dibuat dari kitosan larut air (Water-Soluble Chitosan/ WSC) dengan penambahan alginat dan Sodium Dodesil Sulfat (SDS). Cangkang kapsul dibuat dengan variasi komposisi WSC:Alginat yakni 2:1, 3:1, 4:1, 5:1 dan 6:1 (w/w) dengan dan tanpa penambahan SDS 0,08%. WSC disinteis dari kitosan udang melalui proses depolimerisasi. SDS ditambahkan ke dalam komposisi larutan gel WSC-Alginat sebanyak 5 mL untuk meningkatkan kualitas cangkang kapsul yang dihasilkan. Cangkang kapsul yang berhasil dicetak, kemudian dievaluasi sesuai standar Farmakope Indonesia. Kesergaman bobot cangkang kapsul WSC-Alginat-SDS memenuhi standar Farmakope Indonesia dengan prosentase beda tidak lebih dari 10%. Hasil dari uji yang dilakukan menunjukkan bahwa cangkang kapsul dengan variasi komposisi WSC 6:1 Alginat+SDS memiliki prosentase pengurangan massa sebesar 67,18% dalam air dan 62,15% dalam HCl 0,1 N, prosentase derajat swelling 59,3% dalam air dan 94,51% dalam HCl 0,1 N pada menit ke-10, waktu rilis obat 52 detik dalam air dan 1 menit 6 detik dalam HCl 0,1 N. Waktu kelarutan cangkang kapsul WSC 6:1 Alginat+SDS dalam air memenuhi standar Farmakope Indonesia yakni lebih dari 15 menit. Sedangkan waktu kelarutan dalam HCl 0,1 N lebih dari 5 menit. Spektra FTIR dari cangkang kapsul menunjukkan adanya vibrasi dari molekul-molekul penyusun kitosan, alginat dan SDS. Berdasarkan data penelitian, diperoleh bahwa cangkang kapsul dengan variasi komposisi WSC 6:1 Alginat+SDS merupakan yang paling optimal dan memenuhi standar Farmakope Indonesia untuk digunakan sebagai material drug delivery system.
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Capsule shell has been synthesized from water-soluble chitosan (WSC), alginate and Sodium Dodecyl Sulfate (SDS). The capsule shell were made with mass variations ratio of WSC:Alginate which are 2:1, 3:1, 4:1, 5:1 and 6:1 (w/w) with and without SDS 0,08% (w/v). WSC has been synthesized from shrimp chitosan by depolimerization process. The volume of SDS used 5 mL of each composites to imrove the quality of the capsule shell. Characterization of capsule shell were conducted by the Indonesia Pharmacopeae standard. Weight uniformity test of WSC-Alginate-SDS capsule shell is less than 10% appropiate with the Indonesia Pharmacopeae standard. Based on test data, it showed that capsule shell with mass variations ratio WSC 6:1 Alginat+SDS has percentage weight loss 67,18% in water and 62,15% in 0,1 N HCl, swelling test data in water and 0,1 N HCl that is 59,3% and 94,51%. Drug release time of WSC 6:1 Alginate+SDS capsule shell is about 52 seconds in water and 1 minute 6 seconds in 0,1 N HCl. Capsule shell with mass variations ratio WSC 6:1 Alginate+SDS has dissolution time more than 15 minute that appropiate with the Indonesia Pharmacopeae standard. While in 0,1 N HCl, the dissolution time more than 5 minute. Based on FTIR spectra showed that the obtained capsule shell had vibration from its constituent molecules, i.e. chitosan, alginate and SDS. Based on research data obtained that the capsule shell with mass variations ratio WSC 6:1 Alginate+SDS that most appropiate with the Indonesia Pharmacopeae standard as material of drug delivery system.
| Item Type: | Thesis (Other) |
|---|---|
| Uncontrolled Keywords: | Capsule shell, Water-Soluble Chitosan, SDS, FTIR, weight uniformity test, degradation, swelling, drug release time, dissolution |
| Subjects: | Q Science > QD Chemistry > Polymerization Q Science > QD Chemistry > QD75.2 Chemistry, Analytic |
| Divisions: | Faculty of Natural Science > Chemistry > 47201-(S1) Undergraduate Thesis |
| Depositing User: | Febby Fedika Elanda |
| Date Deposited: | 11 Dec 2023 07:07 |
| Last Modified: | 11 Dec 2023 07:07 |
| URI: | http://repository.its.ac.id/id/eprint/64357 |
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