Haji, Helmi Son (2019) Analisa Pengaruh Konsentrasi Cetyltrimethyl Ammonium Bromide (CTAB) terhadap Disolusi Rata-Rata Piroxicam pada Nanopartikel Silika Mesopori MCM-41. Other thesis, Institut Teknologi Sepuluh Nopember.
Preview |
Text
Helmi Son Haji-02511540000100-Undergraduate Theses.pdf Download (6MB) | Preview |
Abstract
Sekam padi merupakan limbah pertanian yang dapat diekstraksi menghasilkan silika dengan kemurnian yang tinggi. Silika dari sekam padi dapat digunakan sebagai bahan sintesis silika mesopori. Silika mesopori dimanfaatkan sebagai material pengantar obat yang dapat meningkatkan disolusi piroxicam. Penelitian ini bertujuan untuk menganalisisa kemampuan silika mesopori dalam meningkatkan disolusi piroxicam. Penelitian ini dibagi menjadi 3 tahap yaitu sintesis silika, sintesis silika mesopori dan proses enkapsulasi piroxicam ke dalam silika mesopori. Konsentrasi CTAB divariasikan pada 1%, 1.25%, 1.5%, 1.75% dan 2%. Hasil BET menunjukkan bahwa penambahan konsentrasi CTAB berbanding lurus dengan peningkatan disolusi piroxicam. Berdasarkan uji TGA-DSC kapasitas enkapsulasi dengan nilai paling tinggi adalah silika 1.5%CTAB yang mampu mengadsorbsi piroxicam sebanyak 44.66%. Berdasarkan uji spektrofotometri uv-vis didapatkan kemampuan disolusi terbaik pada menit ke 5, 10, 15, 30, 45, 60 sebesar 11.04 mg/l, 9.62 mg/l, 9.62 mg/l , 12.0 mg/l, dan 13.20 mg/l dan 13.6 mg/l.
=================================================================================================================================
Rice husk is an agricultural waste that can be extracted to produce high purity silica. Silica from rice husk can used as a material for synthesis of mesoporous silica. Mesoporous silica can be used as a drug delivery material that can increase the dissolution rate of piroxicam. This study aims to analyze the ability of mesoporous silica in increasing the dissolution rate of piroxicam. This study was divided into 3 stages, silica synthesis, mesoporous silica synthesis and the encapsulation process of piroxicam into mesoporous silica. The CTAB Concentration is divided into 1%, 1.25%, 1.5%, 1.75% and 2%. Based on the results of BET,The addition of CTAB concentration is directly proportional to the increase in dissolution of piroxicam. Based on TGA-DSC ilica 1.5%CTAB has highest encapsulation capacity which can adsorb piroxicam as much as 44.66%. It has dissolution ability at 5, 10, 15, 30, 45, 60 minutes of 11.04 mg / l, 9.62 mg / l, 9.62 mg / l, 12.0 mg / l, and 13.20 mg / l and 13.6 mg / l.
| Item Type: | Thesis (Other) |
|---|---|
| Additional Information: | RSMt 620.118 Haj a-1 2019 |
| Uncontrolled Keywords: | Sekam padi, silika mesopori, konsentrasi, CTAB, piroxicam |
| Subjects: | T Technology > TL Motor vehicles. Aeronautics. Astronautics > TL240.5 Composite materials T Technology > TP Chemical technology T Technology > TP Chemical technology > TP248 Nanogels. Nanoparticles. |
| Divisions: | Faculty of Industrial Technology > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis |
| Depositing User: | Haji Helmi Son |
| Date Deposited: | 30 Jul 2019 06:01 |
| Last Modified: | 21 Feb 2024 04:35 |
| URI: | http://repository.its.ac.id/id/eprint/65255 |
Actions (login required)
 |
View Item |