Desain Larik Perak Nanosquare Komparasi Perak Lapisan Tipis sebagai Elektroda untuk Deteksi Kanker Darah

Farahdina, Ulya (2021) Desain Larik Perak Nanosquare Komparasi Perak Lapisan Tipis sebagai Elektroda untuk Deteksi Kanker Darah. Masters thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Kanker darah merupakan penyakit yang menyebabkan tidak terkendalinya pertumbuhan sel darah putih. Jumlah penderita kanker darah semakin meningkat setiap tahun. Untuk meningkatkan efektivitas deteksi kanker darah, maka dilakukan penelitian mengenai elektroda sebagai alat deteksi kanker darah dengan memfabrikasi dan mengkarakterisasi larik nanosquare dan lapisan tipis Ag sebagai elektroda deteksi kanker darah. Nanosquare Ag dibuat dengan bantuan cetakan Anodic Alumunium Oxide (AAO). Lapisan tipis dan nanosquare Ag dideposisi dengan metode DC sputtering. Setelah itu, dilakukan pengujian mikrostruktur, sifat optik, sifat kelistrikan elektroda dengan variasi konsentrasi dan jenis medium. Hasil simulasi menunjukkan adanya perbedaan persebaran medan listrik yang disebabkan oleh perbedaan jenis medium dan susunan nanosquare. Energi listrik dan magnet maksimum memiliki nilai sebesar 6,64 × 10-15 Joule dan 6,76 × 10-15 Joule yang diperoleh ketika nanosquare dengan ukuran sisi 250 nm dan disinari dengan gelombang elektromagnetik pada panjang gelombang 800 nm. Hasil simulasi dan eksperimen menunjukkan puncak absorbansi nanosquare Ag pada medium darah normal dan kanker secara berturut-turut terletak pada panjang gelombang 700 nm, 750 nm, 800 nm dan 850 nm. Pengujian elektrokimia menunjukkan kenaikan arus puncak oksidasi, penurunan arus puncak reduksi, serta penurunan resistansi elektroda seiring dengan semakin besarnya konsentrasi protein. Nilai sensitivitas elektroda lapisan tipis dan nanosquare Ag untuk mendeteksi darah kanker menggunakan metode siklik voltametri adalah 1,308×10-6 A/mM dan 39,917×10-6 A/mM. Dengan demikian, pengujian sifat optik dan listrik pada lapisan tipis dan nanosquare Ag dapat dijadikan alternatif untuk deteksi dini kanker darah.
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Blood cancer is a disease that causes uncontrolled growth of white blood cells. The number of blood cancer sufferer is increasing every year. To increase the effectiveness of blood cancer detection, a research was conducted on electrodes as a blood cancer detection tool with the fabrication and characterization of nanosquare arrays and thin film of Ag as a blood cancer detection electrodes. Nanosquare Ag was prepared using Anodic Alumunium Oxide (AAO) as a template. Thin film and nanosquare Ag were deposited by DC sputtering method. Then, the microstructure, optical properties, and electrical properties of the electrodes were tested with variations in concentration and type of medium. The simulation results show that there are differences in the electric field distribution caused by different types of medium and nanosquare arrangement. The maximum electric and magnetic energy values are 6.64 × 10-15 Joules and 6.76 × 10-15 Joules which are obtained when a nanosquare with side size of 250 nm is irradiated with electromagnetic waves at a wavelength of 800 nm. Simulation and experimental results show that the absorbance peak of nanosquare Ag in blood and cancer blood medium are at wavelengths 700 to 750 nm and 800 to 850 nm, respectively. Electrochemical tests showed an increase in peak oxidation current, a decrease in peak reduction current, and a decrease resistance of electrode as the protein concentration increased. The sensitivity values of thin film and nanosquare Ag electrodes for detecting cancer blood using the cyclic voltammetry method were 1.308×10-6 A/mM and 39.917×10-6 A/mM. Thus, testing of optical and electrical properties on thin films and nanosquare Ag can be used as an alternative for early detection of blood cancer.

Item Type:	Thesis (Masters)
Uncontrolled Keywords:	Ag, Blood Cancer, Nanosquare, and Thin Film Ag, Kanker Darah, Lapisan Tipis, dan Nanosquare.
Subjects:	R Medicine > RB Pathology T Technology > TN Mining engineering. Metallurgy > TN689+ Physical metallurgy T Technology > TP Chemical technology > TP248 Nanogels. Nanoparticles.
Divisions:	Faculty of Science and Data Analytics (SCIENTICS) > Physics > 45101-(S2) Master Thesis
Depositing User:	Ulya Farahdina
Date Deposited:	23 Aug 2021 09:46
Last Modified:	23 Aug 2021 09:46
URI:	http://repository.its.ac.id/id/eprint/88520

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