Pakpahan, Lehonnita Rotua Lectiodivirani (2022) Pengaruh Fungsionalisasi Polietilen Glikol Terhadap Karakteristik Nanopartikel Magnetit Bersalut Silika Sebagai Media Pengobatan Kanker Melalui Terapi Hipertermia. Other thesis, Institut Teknologi Sepuluh Nopember.
![[thumbnail of 02511840000098-Undergraduate_Thesis.pdf]](http://repository.its.ac.id/style/images/fileicons/text.png) |
Text
02511840000098-Undergraduate_Thesis.pdf Download (10MB) |
Abstract
Terapi hipertermia lokal adalah salah satu pengobatan dengan mengimplementasikan panas dari temperatur 41-45oC pada sel kanker untuk mengurangi resiko matinya sel normal yang ada di sekitar sel kanker. Adapun bentuk dari terapi hipertermia adalah ferrofluid yang mana diperlukan nanopartikel superparamagnetik dari magnetit. Penelitian ini menarik berbagai peneliti karena sifat magnetnya yang baik dengan biokompatibilas baik. Walau demikian, interaksi partikel yang kurang baik dan kecenderungannya untuk agregasi membuat diperlukannya pelapisan pada superparamagnet. Salut silika pada permukaan superparamagnetik dilakukan untuk mengurangi resiko agregasi dan menambah biokompatibilitas pada material. Diaplikasikan juga fungsionalisasi polietilen glikol untuk meningkatkan biokompatibilitas material, serta menjadi carrier pada ferrofluid. Tujuan dari penelitian tersebut adalah menganalisa pengaruh penyalutan silika disertai fungsionalisasi polietilen glikol pada nanopartikel magnetit (Fe3O4-SiO2-PEG) terhadap stuktur kristal dan morfologi nanopartikel, karakterisasi hubungsn material terhadap air, karakteristik sifat magnet dan potensinya untuk digunakan dalam pengobatan kanker dengan terapi hipertermia. Sintesis dilakukan dengan metode sintesis magnetit co-precipitation dan pembentukan salut silika sol-gel. Variasi yang diberlakukan adalah pengaruh konsentrasi TEOS sebagai sumber silika serta rasio partikel terhadap PEG. Selanjutnya sampel dikarakterisasi menggunakan XRD, FTIR, SEM, PSA, hidrofobisitas, surface tension, VSM, serta pengujian pengaruh magnet terhadap temperatur. Fe3O4-SiO2-PEG telah berhasil dilakukan dengan bentuk kubik, tanpa pengaruh pelapisan terhadap ukuran kristal. Bentuk partikel yang teridentifikasi adalah bola dengan modus ukuran terkecil Fe3O4-SiO2 3ml-PEG 2:5 dengan nilai terkecil, terbesar, dan modus secara berurutan 37,84 nm, 396,10 nm, dan 58,77 nm (20%). Interaksi material terhadap air adalah hidrofilik dengan sudut terkecil diperoleh Fe3O4-SiO2 3ml-PEG 4:5 sebesar 39,1o. Nilai surface tension tertinggi didapat oleh Fe3O4-SiO2 4ml-PEG 3:5 senilai 64,4 mN/m. Sifat superparamagnetik telah terjadi dengan momen magnet terbesar diperoleh oleh Fe3O4-SiO2 3ml-PEG 2:5 senilai 51,96 emu/g. Nanopartikel magnetit bersalut silika disertai fungsionalisasi polietilen terbukti berpotensi untuk digunakan sebagai pengobatan kanker terapi hipertermia dengan temperatur akhir tertinggi dengan nilai 32,2oC dan nilai SAR sebesar 87,62 mW/g.
===============================================================================================================================
Local hyperthermia therapy is a treatment by implementing heat from a temperature of 41-45oC on cancer cells to reduce the risk of causing normal cells around cancer cells to die. The form of hyperthermia therapy is in the form of ferrofluid which requires superparamagnetic nanoparticles of iron (III) oxide which has attracted various studies because of its good magnetic properties and good biocompatibility. However, poor particle interactions and their tendency to form aggregations are necessary for coating the superparamagnets. Therefore, silica coating on the superparamagnetic surface is carried out to reduce the risk of aggregation and increase the biocompatibility of the material. Polyethylene glycol functionalization was also applied to improve the biocompatibility of the material, as well as being a carrier for ferrofluid. The purpose of this study was to analyze the effect of silica coating with polyethylene glycol functionalization on magnetic nanoparticles on the crystal structure and morphology of nanoparticles, characterization of the interaction of materials with air, magnetic characteristics, and their potential to be used in the treatment of cancer with hyperthermia therapy. The synthesis was carried out by the synthesis method of magnetite coprecipitation and the formation of a sol-gel silica coating. Variations applied are the effect of the concentration of TEOS as a source of silica and the ratio of particles to PEG. Furthermore, the samples were characterized using XRD, FTIR, SEM, PSA, hydrophobicity, surface tension, and VSM, as well as testing the effect of magnetism on temperature. Silica coating on magnetite nanoparticles accompanied by PEG functionalization has been successfully carried out in a cubic form, without the effect of coating on crystal size. The shape of the small particles is spherical with nanoparticle size mode, obtained 3ml TEOS silica-coated magnetite with PEG 2 functionalization with the smallest, largest, and 37.84 nm, 396.10 nm, and 58.77 nm (20%). The interaction of the material with water is hydrophilic with the smallest angle obtained by magnetite nanoparticles coated with 3ml silica TEOS with PEG 4:5 functionalization of 39.1o. The highest surface tension value was obtained by magnetite nanoparticles coated with silica TEOS 4ml with PEG 3:5 functionalization of 64.4 mN/m. Superparamagnetic properties have occurred with the largest magnetic moment obtained by magnetite nanoparticles coated with PEG TEOS 3ml silica with PEG 2:5 functionalization of 51.96 emu/g. Silica-coated magnetite nanoparticles accompanied by polyethylene excitation were proven to be the best treatment for hyperthermia therapy with the highest final temperature with a value of 32.2oC and a SAR value of 87.62 mW/g.
| Item Type: | Thesis (Other) |
|---|---|
| Additional Information: | RSMt 614.599 9 Pak p-1 2022 |
| Uncontrolled Keywords: | polietilen glikol, silika, superparmagnetik, terapi hipertermia, Hyperthermia therapy, superparamagnetic, silica, polyethylene glycol |
| Subjects: | Q Science > QR Microbiology > QR 201.T84 Tumors. Cancer |
| Divisions: | Faculty of Industrial Technology and Systems Engineering (INDSYS) > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis |
| Depositing User: | Mr. Marsudiyana - |
| Date Deposited: | 11 Feb 2025 07:00 |
| Last Modified: | 11 Feb 2025 07:00 |
| URI: | http://repository.its.ac.id/id/eprint/118650 |
Actions (login required)
 |
View Item |